Current Advances and Future Aspects of Sweetener Synergy: Properties, Evaluation Methods and Molecular Mechanisms

Sweetener synergy is the phenomenon in which certain combinations of sweeteners work more effectively than theoretical sum effects each components. It provides benefits reducing sweetener dosages and improving their sweetness. Many mixtures with synergistic have been reported up to now. Both artificial high-intensity natural are popularly used for synergism, although former seem display potential exhibit latter. Furthermore, several evaluation methods investigate applied, could lead discrepancies results. Moreover, structurally dissimilar cooperatively bind at different sites sweet taste receptor T1R2/T1R3 activate receptor, hydration characters/packing characteristics solvents affect interaction providing preliminary explanations molecular basis synergy. In this article, we firstly present a systematic review, analysis comment on properties, mechanisms Secondly, challenges both theory practice possible strategies overcome these limitations comprehensively discussed. Finally, future perspectives important performance human perception proposed.